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US 2026/0248987 A1Published application
Non-invasive method for predicting the hemoglobin and iron content in prbc units
AssigneeDrk Blutspendedienst Baden-WüRttemberg-Hessen Ggmbh
InventorsJeremy NJOCK EPAH, Richard SCHÄFER, Erhard SEIFRIED
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Abstract
The present invention relates to a non-invasive method for determining and/or predicting total Hb (g) and/or total iron (mg) in a unit of packed red blood cells (pRBC). The method preferably further includes assigning the unit of pRBC to a group of pRBCs suitable for transfusion. The method can furthermore be automated. Additional aspects relate to a data processing apparatus comprising means for carrying out the method, a computer program and a computer-readable medium.
Claims17
A method selected from:
- A) a method for predicting total Hb (g) in a unit of packed red blood cells (pRBC), comprising:
- a) obtaining data for i) the volume (mL) of the unit, ii) the concentration of Hb Fingertip (g/dL), iii) the sex of the donor, and iv) type of blood bag system of the pRBC, and
- b) predicting total Hb (g) in said unit using the following equation
- β
-
- 0
- +
- Unit
-
- volume
-
- (
- mL
- )
-
- β
-
- 1
- +
- Hb
-
- Fingertip
-
- (
- g
- dL
- )
-
- β
-
- 2
- +
- xi
-
- 3
-
- β
-
- 3
- +
- xi
-
- 4
-
- β
-
- 4
- +
- xi
-
- 5
-
- β
-
- 5
- +
- xi
-
- 6
-
- β
-
- 6
- ,
- wherein
- β0=(−33. 97164897288266);
- β1=0.263;
- β2=0.893;
- β3=(−0.386);
- β4=0.386,
- β5=(−0.371);
- 86=0.371, and
- xi3=1 if female, else 0;
- xi4=1 if male, else 0, xi5=1 if blood bag system CQ42271 FRESENIUS KABI DEUTSCHLAND GMBH else 0;
- xi6=1 if blood bag system LQT7248LC MACO PHARMA INT. GMBH else 0;
- B) a method for predicting total iron (mg) in a unit of packed red blood cells (pRBC), comprising
- a) obtaining data for i) the volume (mL) of the unit, ii) the concentration of Hb Fingertip (g/dL), iii) the sex of the donor, and iv) used type of blood bag system of the pRBC, and
- b) predicting total iron (mg) in said unit using the following equation
- (
- β
-
- 0
- +
- β
-
- 1
- *
- Unit
-
- volume
-
- (
- mL
- )
- +
- β
-
- 2
- *
- Hb
-
- Fingertip
-
- (
- g
- dL
- )
- +
- β
-
- 3
- *
- xi
-
- 3
- +
- β
-
- 4
- *
- xi
-
- 4
- +
- β
-
- 5
- *
- xi
-
- 5
- +
- β
-
- 6
- *
- xi
-
- 6
- )
- *
- 4
-
- Fe
- *
- 55.845
- g
- mol
- 64.458
- g
- mmol
- wherein
- β0=(−33. 97164897288266);
- β1=0.263;
- β2=0.893;
- β3=(−0.386);
- β4=0.386,
- β5=(−0.371);
- β6=0.371, and
- xi3=1 if female, else 0;
- xi4=1 if male, else 0, xi5=1 if blood bag system CQ42271 FRESENIUS KABI DEUTSCHLAND GMBH else 0;
- xi6=1 if blood bag system LQT7248LC MACO PHARMA INT. GMBH else 0;
- and
- a method for predicting total iron (mg) and total Hb (g) in a unit of packed red blood cells (pRBC), comprising combining the methods according to parts A) and B) above.
161 more elements
Dependencies are inferred from the claim text.