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US 2026/0248984 A1Published application
Multi-Layered Graft for Tissue Engineering Applications
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Ri.MED Foundation
InventorsAntonio D'Amore, Matteo Solazzo, William R. Wagner
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Abstract
A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.
Claims21
(canceled)
A method of promoting tissue growth in a patient, comprising implanting, in the patient, a multi-layer synthetic graft device comprising:
- a first tubular, porous, biodegradable polymer matrix configured to prevent cellular migration therethrough;
- an ECM gel layer disposed circumferentially about the first porous, biodegradable polymer matrix;
- and
- a second tubular, porous, biodegradable polymer matrix disposed circumferentially about the ECM gel, the second tubular, porous, biodegradable polymer matrix configured to permit cellular migration therethrough.
1 more element
Dependencies are inferred from the claim text.