Aav vector and use thereof

Abstract

The present invention provides an adeno-associated virus (AAV) vector and use thereof. The AAV vector comprises a nucleic acid fragment encoding a secreted tat-degradation peptide. The AAV vector designed in the present invention can be continuously expressed in the peripheral nervous system, where the expressed degradation peptides can cross the blood-brain barrier and cell membranes to exert long-term therapeutic effects in central nervous system (CNS) diseases. Additionally, the vector can also be continuously expressed in the CNS, where the degradation peptides cross the cell membrane to mediate its effects in both AAV-infected and non-infected cells. Therefore, the present invention offers an AAV vector that enables widespread and long-acting delivery of a therapeutic degradation peptide.

Dependencies are inferred from the claim text.