Lipid microbubbles for the targeted delivery of active agents

Abstract

The present invention concerns optimized microbubbles, in particular lipid microbubbles, which can be used in the prevention and treatment of diseases or for marking. The invention relates in particular to a lipid microbubble, comprising at least one cationic compound selected from lipophosphoramidates, histidylated polyethylenimines, and any mixture thereof. The microbubble preferably further comprises at least one agent selected from a therapeutic agent, a targeting agent, a marking agent, and any combination thereof. The invention also relates to a method for producing this microbubble. The present invention also relates to a composition, in particular a pharmaceutical composition, and a kit, comprising at least one of these microbubbles. The present invention also relates to the use of these microbubbles, composition, kit, as a medicament or as a marking agent.

Dependencies are inferred from the claim text.