Cationic amphiphilic polypeptide for delivering rna and method for preparing the same
AssigneeInha University Research and Business Foundation
InventorsHyun Jin KIM, Jun Su AN
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Abstract
The present disclosure relates to a cationic amphiphilic polypeptide for delivering RNA and a method for preparing the same, wherein it was found that a polypeptide polymer, which is obtained by binding a conjugate in which diethylenetriamine (DET) is bonded to aspartic acid; and a conjugate in which octylamine (OCT) is bonded to aspartic acid in a specific order, exhibits superior mRNA transcription efficiency to a polymer bonded in a different order, such that it may be useful as the polypeptide polymer, a method for preparing the same, or a composition for delivering RNA including the same.
Claims11
A polypeptide polymer represented by the following Chemical Formula 1:
- wherein, in the Chemical Formula 1,
- n is one of 1 to 20,
- a and b may be the same or different and are each independently one of 1 to 5,
- c and d may be the same or different and are each independently one of 1 to 20, and
- R1 and R2 may be the same or different and are each independently hydrogen or (C4-C12)cycloalkyl.
Dependencies are inferred from the claim text.