Bi-specific adapters and their use with universal car-t cells in the treatment of tumors and the inhibition of cancer-associated fibroblasts
AssigneePurdue Research Foundation
InventorsPhilip Low, Haiyan A. Chu, Bo Huang, Sudarsan Kasireddy, Yashapal Singh, Suilan Zheng, Madduri Srinivasarao, Ramesh Mukkamala
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Abstract
Chimeric antigen receptor (CAR)-T cells, bispecific adapters that link the CAR-T cells to tumor cells and/or cancer-associated fibroblasts (CAFs), and methods of treating cancer using same.
Claims55
A bispecific adapter comprising the following structure:
- or a pharmaceutically acceptable salt or hydrate thereof, wherein:
- F comprises a fluorescein, fluorescein isothiocyanate (FITC), or N-hydroxysuccinimide (NHS)-fluorescein,
- L comprises a linker, and
- TL comprises a targeting ligand comprising a radical of a fibroblast activation protein (FAP) ligand or a radical of a prostate-specific membrane antigen (PSMA) ligand.
A bispecific adapter for use with an anti-fluorescein chimeric antigen receptor (CAR)-T cell in the treatment of a fibroblast activation protein (FAP)-expressing cancer, which adapter has or comprises one of the following structures:
- or comprising a pharmaceutically acceptable salt or hydrate ofany of the foregoing structures.
A bispecific adapter for use with an anti-fluorescein chimeric antigen receptor (CAR)-T cell in the treatment of a fibroblast activation protein (FAP)-expressing cancer, which adapter has or comprises one of the following structures:
- or comprising a pharmaceutically acceptable salt or hydrate of any of the foregoing structures.
A bispecific adapter for use with an anti-fluorescein chimeric antigen receptor (CAR)-T cell in the treatment of a prostate-specific membrane antigen (PSMA) cancer, which adapter has or comprises one of the following structures:
- or comprising a pharmaceutically acceptable salt or hydrate of any of the foregoing.
A bispecific adapter for use with an anti-fluorescein chimeric antigen receptor (CAR)-T cell in the treatment of prostate-specific membrane antigen (PSMA)-expressing cancer, which adapter has the structure:
- a pharmaceutically acceptable salt or hydrate thereof.
A bispecific adapter for use with an anti-fluorescein chimeric antigen receptor (CAR)-T cell in the treatment of prostate-specific membrane antigen (PSMA)-expressing cancer, which adapter has the structure:
- or is a pharmaceutically acceptable salt or hydrate thereof.
Dependencies are inferred from the claim text.