Compositions and methods of suppressing aversiveness of pharmaceuticals and ingestible materials

A method of suppressing the taste of an active pharmaceutical ingredient (API) which causes aversiveness in a subject upon oral administration comprises:

• (a) orally administering to the subject in need thereof a pre-rinse composition comprising:
• i. one or more compounds of Formula A
• wherein R2, R5, R6, R7, R8, R2′, R3′, R4′, R5′, and R6′, are independently selected from H, OH, a C1 to C10 alkyl, C2 to C10 alkenyl, C2 to C10 alkynyl;
• C1 to C10 alkoxy, or a substituted alkyl, alkenyl or alkynyl, or a halogen;
• ii. carrier and excipient components comprising one or more of sodium salts, zinc salts, sophorolipids, milk or a milk product, and water;
• and
• iii. one or more optional TAS2R blockers other than (i), and
• (b) orally administering to the subject the API or a composition comprising the API;
• wherein the API or a composition comprising the API is administered subsequently following orally administering the pre-rinse composition, wherein the compound of Formula A is 6-methylflavone.