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US 2026/0248905 A1Published application
muNS FUSION PROTEIN CAPABLE OF FORMING MICROSPHERES AND USES THEREOF
AssigneeUniversidade De Santiago De Compostela
InventorsDANIEL LÓPEZ ABELLA, NATALIA BARREIRO PIÑEIRO, ADRIÁN LÓPEZ TEIJEIRO, JOSÉ MANUEL MARTÍNEZ COSTAS
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Abstract
The invention relates to a fusion protein encoding a polypeptide based on the minimal region of the Orthoreovirus muNS protein capable of forming microspheres and/or nanospheres, modified to permit the addition of polypeptides at the C-terminal.
Claims22
1-66. (canceled)
A fusion protein comprising the following components:
- (i) a polypeptide comprising a sequence selected from the group consisting of:
- sequence 448-635 (SEQ ID NO:
- 1) of the avian Orthoreovirus muNS protein,
- sequence 518-721 (SEQ ID NO:
- 2) of the mammalian Orthoreovirus muNS protein, and
- a functionally equivalent variant of any of the above with the capacity to form nanospheres and/or microspheres, and
- (ii) a polypeptide selected from:
- (a) a polypeptide comprising the sortase recognition motif or the residual part of a sortase recognition motif generated after a sortase-mediated reaction, wherein component (ii) is fused to the carboxyl end of component (i), or
- (b) a polypeptide comprising the sortase acceptor motif, wherein component (ii) is fused to the amino end of component (i).
6 more elements
Dependencies are inferred from the claim text.