Dna vaccine for fish against salmonid alphavirus
AssigneeIntervet Inc.
InventorsStephane VILLOING, Martijn Alexander LANGEREIS, Christiaan VOSSEN
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Abstract
Salmonid alphavirus (SAV) is an important pathogen affecting the aquaculture of Salmonid fish. Vaccines based on DNA plasmids expressing a SAV antigen have been described. However these are difficult to prepare at large scale and at the desired quality level. Also, they are commonly administered at relatively high amounts of plasmid per animal dose. This makes such DNA vaccines less affordable for this market. The invention discloses an improved plasmid that allows effective use as a DNA vaccine against SAV, but at a much reduced amount of DNA per dose. The plasmid contains a gene encoding a bacterial enzyme: Fab.
Claims21
A plasmid comprising a gene encoding an antigen from salmonid alphavirus (SAV) and a eucaryotic promoter operably linked to said gene, wherein said plasmid also comprises a fab gene.
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A method to increase the efficacy of the plasmid in a SAV DNA vaccine, the method comprising the step of inserting a fab gene into said plasmid.
Dependencies are inferred from the claim text.