Withania somnifera composition for improving memory and cognition
AssigneeArjuna Natural Private Limited
InventorBenny ANTONY
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Abstract
The present invention relates to a medicinal composition derived from Withania somnifera extract comprising withanolides and sominone wherein said sominone in the extract is standardized in the range of 0.1-30%. Withanolides in the said composition are in the range of 10-60%. It is further comprising withanolide glycosides and withaferin A. Medicinal composition along with pharmaceutically acceptable excipients are formulated into a dosage form. It also discloses a method of preparation of said medicinal composition. Said composition is used to improve memory and cognition when administered to subjects in the appropriate dosage. Said composition is capable of enhancing the bioavailability of its constituents.
Claims18
1-27. (canceled)
A medicinal composition derived from Withania somnifera extract comprising withanolides and sominone wherein said sominone in the Withania somnifera extract is standardized in the range of 0.1-30%.
A method of preparing a medicinal composition derived from a Withania somnifera extract comprising the steps of
- a) cleaning an Ashwagandha plant part (root and leaf);
- (b) drying the cleaned plant part and powdering it;
- (c) extracting the powdered part using a polar solvent;
- (d) collecting the supernatant after extracting and followed by concentrating to obtain a concentrate;
- (e) subjecting said concentrate to liquid-liquid extraction using a nonpolar solvent;
- (f) separating an aqueous and a solvent part after the liquid-liquid extraction;
- (g) subjecting the aqueous part in step (f) to column purification using water and methanol;
- (h) collecting the water elute and the methanol elute and keeping aside;
- (i) subjecting the solvent part collected in step (f) to column purification by eluting with hexane-methanol in different ratios and collecting different fractions;
- (j) blending the methanol elute of step (h) and one of the fractions from step (i) containing a higher percentage of actives to obtain the extract of Withania somnifera, and
- (k) preparing the medicinal composition comprising the extract of Withania somnifera.
A dosage form comprising a medicinal composition derived from a Withania somnifera extract, wherein the Withania somnifera extract comprises withanolides and sominone, and wherein the sominone in the extract is standardized in the range of 0.1% to 30%.
Dependencies are inferred from the claim text.