Pyrimidine nucleoside treatments
AssigneeChildren’s Medical Center Corporation
InventorsSuneet Agarwal, William Mannherz
Life of this patent
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Abstract
The present disclosure provides pyrimidine nucleoside compounds, including torcitabine, thymidine, deoxyuridine, deoxycytidine and uridine, and methods to treat telomere biology disorders (TBDs) and aging-related diseases, including hematological disorder, liver disease, or hepatic fibrosis, comprising administering to a subject diagnosed with said telomere biology disorder a therapeutically effective amount of said compounds.
Claims25
A method of treating a telomere biology disorder, the method comprising administering to a subject diagnosed with said telomere biology disorder a therapeutically effective amount of a compound of Formula (A):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from H and OH;
- R2 is selected from any one of the following moieties:
- and
- R3 is selected from H and CH3.
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Dependencies are inferred from the claim text.