Methods for treating testicular and ovarian adrenal rest tumors

A method of decreasing or reducing androstenedione levels in a subject in need thereof, comprising administering to the subject a small molecule corticotropin-releasing factor type-1 (CRF1) antagonist, or a pharmaceutically acceptable salt thereof, wherein the small molecule CRF1 antagonist is:

• or a pharmaceutically acceptable salt thereof,
• wherein the plasma concentration of A4 is reduced by at least 25% from baseline, and
• wherein the subject is in a fed state.