Use of non-toxic polyamine analogues and/or inhibitors of polyamine biosynthesis to re-balance natural polyamine levels in snyder-robinson syndrome and related disorders
AssigneeThe Johns Hopkins University
InventorsRobert A. CASERO, Tracy Murray STEWART
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Abstract
Methods for treating Snyder-Robinson Syndrome or related disorders by administering a polyamine analogue in combination with an inhibitor of polyamine biosynthesis are disclosed.
Claims11
A method for treating a disease, condition, or disorder associated with a decrease in biosynthesis of spermine and/or an elevated spermidine/spermine level, the method comprising administering to a subject in need of treatment thereof a therapeutically effective amount of a polyamine analogue or an inhibitor of polyamine biosynthesis, such as a an ornithine decarboxylase (ODC) inhibitor or a spermidine synthase (SRM) inhibitor, or a combination thereof, to treat disease, condition, or disorder.
A composition comprising a polyamine analogue and an inhibitor of polyamine biosynthesis and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.