Method for cartilage regeneration and regrowth following injury
AssigneeEluciderm Inc.
InventorsDaniel Holsworth, Sarika Saraswati
Life of this patent
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Abstract
A method for enhancing cartilage regeneration following its wounding is provided which includes identifying a mammal as experiencing an injury to its cartilage applying to it a composition including graphene oxide (GO) and hyaluronic acid (HA) that are covalently linked, XAV939, and water. The composition of the method may also include a surfactant, such as PEG. The composition can be topically administered to a subject to treat cartilage wounding of the subject.
Claims22
A method for stimulating regeneration of mammalian cartilage subject to an injury comprising:
- optionally identifying a mammal as experiencing an injury to cartilage;
- optionally identifying the location and extent of the cartilage subject to an injury;
- and
- contacting of said cartilage subject to an injury with an effective amount of a composition, the composition comprising
- a matrix component comprising a graphene oxide (GO) and hyaluronic acid (HA) conjugate (GO-HA), wherein the GO and HA are covalently linked via a linker;
- 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one (XAV939);
- and
- water;
- optionally wherein XAV939 constitutes from about 0.001 wt % to about 5 wt % of the total composition.
-60. (canceled)
A pharmaceutical composition comprising 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one (XAV939), wherein the pharmaceutical composition is a liposomal composition and wherein the pharmaceutical composition comprises XAV939;
- a matrix component comprising a graphene oxide (GO) and hyaluronic acid (HA) conjugate (GO-HA), wherein the GO and HA are covalently linked via a linker;
- water;
- and a phospholipid.
Dependencies are inferred from the claim text.