Treatment of asthma and copd with pulsed electric field ablation and precision drug delivery

A method of treating respiratory maladies and malformations, comprising:

• deploying a first catheter into a lung of a patient or subject;
• suctioning sputum from a lung of a patient or subject by a suctioning means;
• activating one or more electrodes disposed on or within the first catheter, thereby delivering pulsed electrical therapy for ablation of a treatment site within a lung of a patient or subject;
• and
• delivering a drug and/or therapeutic to the treatment site.

A pulsed-electric-field ablation catheter, comprising:

• a proximal shaft;
• a control knob;
• a distal shaft including a distal tip disposed at a distal end of the distal shaft;
• wherein the control knob is disposed proximate the proximal shaft and the distal shaft;
• wherein the ablation catheter includes one or more electrodes disposed upon or within an expandable framework;
• wherein the expandable framework further includes one or more drug coatings or one or more drug dispensing elements disposed upon or within the expandable framework;
• and
• wherein both the proximal shaft and the distal shaft include at least one common lumen configured to receive the one or more electrodes, one or more drugs, and/or one or more therapeutics therethrough.