Gastric myoelectrical signature of feeding readiness in preterm infants
AssigneeBoard of Regents, The University of Texas System
InventorsEric Brum Ortigoza, Hanli Liu
Life of this patent
Estimating the term…
Abstract
Provided herein are methods of predicting and/or diagnosing mammalian infants with feeding intolerance or feeding tolerance based on electrogastrography data. Further provided herein are methods of distinguishing between developmental and pathological feeding intolerance in preterm infants. The methods disclosed herein may be used to inform on suitable treatment for preterm infants with feeding intolerance.
Claims22
A method of predicting and/or diagnosing feeding intolerance (FI) in a subject in need thereof, the method comprising:
- (a) providing pre- and during feeding electrogastrography (EGG) signal data from at least one feed for the subject;
- (b) obtaining mean power ratios mPRdur/pre (mean power ratio of during and pre-feeding signal) from power spectral density (PSD) obtained from during and pre-feeding EGG signals;
- and
- (c) predicting/diagnosing feeding intolerance in the subject if the mPRdur/pre ratio is less than or equal to one.
(canceled)
A method of treating a preterm infant in need thereof for a feeding intolerance (FI) comprising:
- I. determining a mean power ratio mPRdur/pre using the steps of:
- (a) providing pre- and during feeding electrogastrography (EGG) signal data from at least one feed for the preterm infant;
- and
- (b) obtaining mean power ratios mPRdur/pre from power spectral density (PSD) obtained from during and pre-feeding EGG signals, and
- II. administering a treatment to the preterm infant, wherein the preterm infant has been determined to have the mPRdur/pre ratio of less than or equal to one.
-22. (canceled)
A computer implemented method for predicting/diagnosing feeding intolerance (FI) in a subject in need thereof, the method comprising:
- (a) providing pre- and during feeding electrogastrography (EGG) signal data from at least one feed for the subject;
- (b) obtaining mean power ratios mPRdur/pre from power spectral density (PSD) obtained from during and pre-feeding EGG signals;
- and
- (c) predicting/diagnosing feeding intolerance in the subject if the mPRdur/pre ratio is less than or equal to one;
- (d) predicting/diagnosis no feeding intolerance (NFI) in the subject if the mPRdur/pre ratio is greater than one.
A system for predicting/diagnosing feeding intolerance (FI) in a subject, the system comprising:
- (a) an EGG machine;
- (b) a memory;
- and
- (c) a processor operable to execute instructions stored in the memory to determine mean power ratios mPRdur/pre from power spectral density (PSD) obtained from during and pre-feeding EGG signals from the subject.
Dependencies are inferred from the claim text.