System and Method for Parallelized 3D Measurement of Multicellular Specimens

Abstract

Disclosed is a system for imaging multi-well plates. The system comprises a micro-camera array, an illumination array, a scanning mechanism, a controller and a processor. The scanning mechanism moves the micro-camera and illumination arrays in three dimensions relative to the multi-well plate. The controller positions the arrays, activates illumination and captures image data. The processor generates 3D (three-dimensional) measurements of specimens within wells. The processor maps image data to per-specimen 3D measurements, generates statistical data and tracks specimens longitudinally. The system provides even illumination across wells using optimized optical elements and a polymer-dispersed liquid crystal sheet. Thus, the system enables rapid 3D imaging and analysis of specimens across high-density well plates, allowing high-throughput 3D imaging and analysis of multicellular specimens.

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