System, device and methods of sample processing using semiconductor detection chips

A fluid sample adapter comprising:

• a planar frame defining a fluidic path between a first planar substrate and a second planar substrate;
• a fluidic interface at one end of the planar frame, the fluidic interface comprising a fluid inlet and fluid outlet of the fluidic path;
• and
• a flowcell interface configured to couple with a flowcell adapter, wherein the flowcell interface includes a first set of ports in fluid communication with the fluidic path to facilitate flow of fluid sample introduced into the fluid sample adapter from the fluid inlet into the flowcell.

A flowcell adapter comprising:

• a planar frame configured to couple with a fluid sample adapter;
• a flowcell chamber defined within the planar frame;
• and
• one or more flowcell ports in fluid communication with the flowcell chamber, the one or more flowcell port configured to sealingly couple with a first set of ports in a fluid sample adapter when coupled thereto.