US 2026/0243794 A1 · ROBOTIC PIPETTES CALIBRATION SYSTEM, METHOD OF USE, AND AUXILIARY DEVICES

Abstract

A system and method for semi-automatic pipette calibration of any air-displacement type of pipette in a time efficient manner. The system including a pipette holder configured to carry a plurality of pipettes, each of the plurality of pipettes adjusted to aspirate water of a specific calibration volume; a robotic arm comprising a gripper configured to hold any air-displacement type of pipette, a tip storage compartment comprising multiple different sized cells configured to carry different sized tip cartridges for holding a different size of tips; a tip cartridge bay configured to fixate the cartridge at a specific location within the cartridge bay; a water basin; at least one scale for weighing water extracted from the water basin by each of the plurality of pipettes; a control system; and a user interface configured to display information related to the semi-automatic calibration.

Claims20

Dependent claims

A method for calibration of a plurality of pipettes of any air-displacement type, compatible with the International Standard ISO 8655-6:2022, said method comprising:

(a) adjusting a first calibration volume in each of the plurality of pipettes, said adjusting is performed manually;
by an automated system:
(b) extracting a pipette from a pipette holder;
(c) attaching a corresponding tip to a pipette distal end;
(d) immersing a tip distal end into a water dispenser;
(e) aspirating water from the water dispenser into the tip according to the adjusted first calibration volume;
(f) extracting the water from the tip onto a scale;
(g) weighing the extracted water by the scale;
(h) repeating operations (d)-(g) for a predetermined number of times;
(i) after completion of operations (d)-(g) for the predetermined number of times, removing the tip from the pipette;
(j) calculating average volume of the water of operations (d)-(h) by a processor;
(k) repeating operations (c)-(j) for another predetermined number of times;
(l) returning pipette back to the pipette holder by the robotic arm;
and
(m) repeating operations (b)-(l), by the robotic arm, until all of the plurality of pipettes are calibrated per the first calibration volume.

12 more elements

A system for calibration of a plurality of pipettes of any air-displacement type, compatible with the International Standard ISO 8655-6:2022, said system comprising:

a pipette holder configured to carry a plurality of pipettes of any air-displacement type, each of said plurality of pipettes adjusted to aspirate water of a specific calibration volume;
a robotic arm comprising a gripper configured to hold any air-displacement type of pipette, said gripper comprising two moveable arms, each having a non-rigid face that comes in contact with a pipette, wherein the moveable arms are configured to contract for gripping a pipette in between the two non-rigid faces of the moveable arms, and to expand for releasing the pipette from the gripper;
a water dispenser;
at least one scale for weighing water extracted from the water dispenser by each of the plurality of pipettes;
a control system;
and
a user interface configured to display information related to calibration.

4 more elements

Dependencies are inferred from the claim text.

Robotic pipettes calibration system, method of use, and auxiliary devices

Life of this patent

Robotic pipettes calibration system, method of use, and auxiliary devices

Life of this patent

Abstract

Claims20