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US 2026/0243777 A1Published application
Peptide decorated nanoparticles for enrichment of specific protein subsets
AssigneeSeer, Inc.
InventorsAsim SIDDIQUI, Daniel HORNBURG, Craig STOLARCZYK, Yina LI, Hongwei XIA
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Abstract
The present disclosure provides a range of compositions and methods for enriching subsets of complex biological samples. Aspects of the present disclosure provide peptide-functionalized particles comprising affinities for subsets of biomolecules from complex biological samples. The present disclosure further provides methods for utilizing functionalized particles to fractionate and analyze complex biological samples.
Claims23
A system for enriching proteins from a sample comprising:
- at least two distinct particle types each comprising a surface bound peptide having binding specificity for a different set of proteins of the sample, wherein:
- (a) each peptide comprises at most 40 amino acids;
- (b) each peptide has a different isoelectric point;
- and
- (c) each of the at least two distinct particle types comprise a plurality of biomolecules from the sample adsorbed on its surface, and wherein each of the plurality of biomolecules comprises at least 100 proteins.
2 more elements
Dependencies are inferred from the claim text.