Gdv optimized injection with sample pre-compression
AssigneeDionex Softron GmbH
InventorThomas Wachinger
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Abstract
The present invention relates to a method for operating a chromatography system, wherein the chromatography system comprises a pump, a metering device, a sample loop, a separation column, and an injection valve, the method comprising injecting a sample stored in the sample loop into the separation column, without the metering device being part of an analytical path, and injecting a sample stored in the sample loop into the separation column with the metering device being part of the analytical path, wherein the analytical path denotes a flow path between the pump and the separation column. Further, the present invention relates to a respective system and computer program product.
Claims13
Method for operating a chromatography system, wherein the chromatography system comprises a pump, a metering device, a sample loop, a separation column, and an injection valve, the method comprising
- injecting a sample stored in the sample loop into the separation column, without the metering device being part of an analytical path;
- and
- injecting a sample stored in the sample loop into the separation column with the metering device being part of the analytical path;
- wherein the analytical path denotes a flow path between the pump and the separation column.
A chromatography system comprising
- an injection valve comprising at least 6 ports,
- a pump,
- a separation column,
- a metering device,
- a sample loop,
- a sample pickup means, and
- a seat configured to receive and fluidly connect to the sample pick up means;
- wherein the system is configured to assume a first injection configuration, wherein an outlet of the pump is fluidly connected to an inlet of the separation column and wherein a resulting flow path between the pump and the separation column comprises the sample loop, the sample pickup means, and the seat, but not the metering device;
- and
- wherein the system is configured to assume a second injection configuration, wherein the outlet of the pump is fluidly connected to the inlet of the separation column and wherein a resulting flow path between the pump and the separation column comprises the metering device, the sample loop, the sample pickup means and the seat.
Dependencies are inferred from the claim text.