Biomarker detection using surface-enhanced infrared spectroscopy

Abstract

A method includes determining a first change from a first FTIR spectrum of bare SEIRA structures to a second FTIR spectrum of SEIRA structures bound with complementary molecules; determining a second change from the second FTIR spectrum to a third FTIR spectrum of SEIRA structures bound with the complementary molecules and the target molecules; and determining a presence and/or a concentration of the target molecule. The method may include determining an area ratio indicative of a concentration of the target molecule. A device includes a plurality of wells to receive an amount of the sample. Each well is isolated from any other of the plurality of wells. A SEIRA sensor is disposed in each well, in which the SEIRA sensor is configured with a resonant response in a plurality of resonant peak frequencies distributed over a range of frequencies.

Dependencies are inferred from the claim text.