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US 2026/0242872 A1Published application
Long non-coding rna as therapeutic target in cardiac disorders and cardiac regeneration
AssigneeMedizinische Hochschule Hannover
InventorsThomas THUM, Cheng-Kai HUANG, Christian BÄR
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Abstract
The present invention relates to a long non-coding RNA as a therapeutic target in cardiac disorders.
Claims8
A method for treating a cardiac disorder in a subject, the method comprising administering to the subject an effective amount of a nucleic acid molecule comprising:
- (i) a nucleotide sequence of SEQ ID NO:
- 1, 2, 3, 4 or 5, wherein the nucleic acid of—SEQ ID NO:
- 1, 2, 3, 4 or 5 increases viability and/or proliferation of cardiomyocytes,
- (ii) a nucleotide sequence which has an identity of at least 70%, at least 80%, at least 90% or at least 99% to any one of SEQ ID NO:
- 1, 2, 3, 4, or, 5, wherein the percentage of identity is determined over the whole length of SEQ ID NO:
- 1, 2, 3, 4 or 5, or
- (iii) a nucleotide sequence which is complementary to the nucleotide sequence of the nucleic acid molecule of (i) or (ii) over the whole length of the two sequences.
4 more elements
Dependencies are inferred from the claim text.