Respiratory vectors and uses thereof
AssigneeAldevron, LLC
InventorsRicardo SALDANA-MEYER, Jin HUH, Jodi KENNEDY
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Abstract
The application provides circular DNA vectors comprising promoters, scaffold matrix attachment region (S/MAR) sequences, and transgenes derived from proteins expressed in respiratory epithelium and which lack drug resistance genes. The application provides pharmaceutical compositions comprising therapeutic amounts of the DNA vectors.
Claims46
A circular DNA vector comprising a promoter, a transgene, and a scaffold matrix attachment region (S/MAR) sequence, wherein the transgene is a therapeutic protein-encoding sequence derived from a protein expressed in respiratory epithelium, and wherein the circular DNA vector lacks a drug resistance gene.
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A nucleic acid vector comprising a hypersensitivity sequence operably linked 5′ to a transgene, wherein the hypersensitivity sequence comprises SEQ ID NO:
- 5, or a functional variant thereof.
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Dependencies are inferred from the claim text.