Tissue engineered tube using stem cell, and method for producing same
AssigneeTohoku University
InventorsShun Itai, Takafumi Toyohara
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AssigneeTohoku University
InventorsShun Itai, Takafumi Toyohara
Estimating the term…
The present inventions is to produce a tissue engineered tube including a smooth muscle layer and an endothelial cell layer derived from stem cells. It is possible to produce a tissue engineered tube that generates physiological contraction and relaxation reactions by producing a tissue engineered tube using smooth muscle cells derived from stem cells at least three times or more as those used in a method of the related art, and using endothelial cells derived from stem cells. Since an artificial blood vessel produced using iPS cells derived from a Werner syndrome patient indicates being an artificial blood vessel reflecting a pathological condition, tissue engineered tubes reflecting pathological conditions of various diseases can be produced using iPS cells. The tissue engineered tube can be used in pharmaceutical screening and transplantation.
1-11. (canceled)
A tissue engineered tube comprising a smooth muscle layer containing a smooth muscle tissue wound in a spiral shape or an annular shape and having a density of 1.0×108 cells/cm3 or more and 1.0×1010 cells/cm3 or less, wherein
A method for producing a tissue engineered tube including a smooth muscle derived from stem cells, the method for producing tissue engineered tube comprising:
Dependencies are inferred from the claim text.