Novel process
AssigneeNanodent S.R.L.
InventorsMargherita De Angelis, Michela Cok
Life of this patent
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Abstract
The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained With the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.
Claims17
A process for obtaining a dental prosthesis comprising a crown and tooth root, this process comprising:
- (a) directing undifferentiated cells towards an odontoblastic phenotype;
- (b) directing undifferentiated cells or keratinocytes towards an ameloblastic phenotype,
- (c) making a bioink available,
- d) three-dimensional (3D) printing of the cells obtained in step a), the cells obtained in step b) and the bioink from step c), resulting in the dental prosthesis;
- and
- e) maintaining the denture obtained in step d) in culture.
A bioink suitable for three-dimensional (3D) printing comprising at least one alginate, at least one gelatine and optionally at least one filler, wherein the at least one alginate is selected from:
- alginate modified with acrylic groups, alginate modified with methacrylic groups and alginate modified with saccharide groups, and wherein the at least one filler is selected from:
- hydroxyapatite, nanohydroxyapatite, a bioglass and combinations thereof.
Dependencies are inferred from the claim text.