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US 2026/0242449 A1Published application
Multispecific anti-hiv antibodies
AssigneeInternational AIDS Vaccine Initiative
InventorsJoseph JARDINE, Mateusz KEDZIOR
Life of this patent
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Abstract
The present disclosure relates to anti-HIV Env antibodies and their use in the treatment or prevention of HIV/AIDS.
Claims45
A multispecific anti-HIV antibody comprising at least two antigen binding domains selected from the group consisting of
- (a) an antigen binding domain that binds to the V3 loop epitope region of HIV Env, wherein the antigen binding domain comprises a VH domain and a VL domain comprising the 3 VH CDRs and 3 VL CDRs, respectively, of ePGT121v2 or ePGT121v1;
- and
- (b) an antigen binding domain that binds to the CD4bs epitope region of HIV Env, wherein the antigen binding domain comprises a VH domain and a VL domain comprising the 3 VH CDRs and 3 VL CDRs, respectively, of N49P7 or an engineered variant of N49P7.
The multispecific antibody of claim 3, wherein the ePGT121v2 VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 comprise the amino acid sequence of SEQ ID NO:
- 19, 20, 21, 23, 24 and 25, respectively, and the ePGT121v1 VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2 and VL CDR3 of ePGT121v1 comprise the amino acid sequence of SEQ ID NO:
- 1, 2, 3, 5, 6, and 7, respectively.
Dependencies are inferred from the claim text.