Immunogenic protein against gonococcal infection
AssigneeGriffith University
InventorsKate SEIB, Evgeny SEMCHENKO
Life of this patent
Estimating the term…
Abstract
This invention relates, inter alia, to an immunogenic fragment of a Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae (SEQ ID NO: 1) for the prevention and treatment of Neisseria gonorrhoeae or gonococcal- or meningococcal-associated diseases and conditions. In some embodiments, the immunogenic fragment corresponds to a C-terminal fragment of the protein (SEQ ID NO: 2).
Claims20
-16. (canceled)
A method of eliciting an immune response to Neisseria gonorrhoeae and/or Neisseria meningitidis bacteria in a subject, comprising administering:
- (i) an immunogenic fragment of an Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae;
- (ii) a protein comprising the immunogenic fragment;
- (iii) a nucleic acid encoding the immunogenic fragment or the isolated protein;
- (iv) a genetic construct comprising the nucleic acid;
- (v) a host cell comprising the genetic construct;
- (vi) an antibody or antibody fragment that binds to or is raised against the immunogenic fragment;
- or
- (vii) a composition comprising the immunogenic fragment and a pharmaceutically-acceptable diluent, carrier or excipient
- to the subject to thereby elicit the immune response.
A method of inducing immunity against Neisseria gonorrhoeae and/or Neisseria meningitidis bacteria in a subject, comprising administering:
- (i) an immunogenic fragment of an Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae;
- (ii) a protein comprising the immunogenic fragment;
- (iii) a nucleic acid encoding the immunogenic fragment or the isolated protein;
- (iv) a genetic construct comprising the nucleic acid;
- (v) a host cell comprising the genetic construct;
- (vi) an antibody or antibody fragment that binds to or is raised against the immunogenic fragment;
- or
- (vii) a composition comprising the immunogenic fragment and a pharmaceutically-acceptable diluent, carrier or excipient
- to the subject to thereby induce immunity against the Neisseria gonorrhoeae and/or Neisseria meningitidis bacteria in the subject.
A method of treating or preventing a Neisseria gonorrhoeae and/or Neisseria meningitidis bacterial infection in a subject, comprising administering:
- (i) an immunogenic fragment of an Neisserial Heparin Binding Antigen (NHBA) protein of Neisseria gonorrhoeae;
- (ii) a protein comprising the immunogenic fragment;
- (iii) a nucleic acid encoding the immunogenic fragment or the isolated protein;
- (iv) a genetic construct comprising the nucleic acid;
- (v) a host cell comprising the genetic construct;
- (vi) an antibody or antibody fragment that binds to or is raised against the immunogenic fragment;
- or
- (vii) a composition comprising the immunogenic fragment and a pharmaceutically-acceptable diluent, carrier or excipient
- to the subject to thereby prevent or treat the Neisseria gonorrhoeae and/or Neisseria meningitidis bacterial infection in the subject.
-24. (canceled)
Dependencies are inferred from the claim text.