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US 2026/0242402 A1Published application
Prodrugs of stat3 inhibitors
AssigneeTvardi Operating Company, Inc.
InventorsImran Alibhai, Sofia de Achaval, Jeffrey Larson, Brad Henke
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Abstract
Provided herein, in certain embodiments, are compounds of Formula I: or a pharmaceutically acceptable salt or a solvate thereof, compositions comprising a compounds of Formula I, or a pharmaceutically acceptable salt or a solvate thereof, and uses thereof such as in treating certain diseases or disorders (e.g., cancer, fibrosis, chronic inflammation).
Claims42
A compound of Formula I:
- or a pharmaceutically acceptable salt or a solvate thereof, wherein
- A is halo, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl, or C1-4haloalkoxy;
- R1, R2, and R3 are each independently H, C(═O)NRARB, P(═O)(OH)(RC), or C1-4 alkylene-O—P(═O)(OH)(RC);
- or
- R1 and R2 together form:
- provided that R1, R2 and R3 are not simultaneously H;
- RA is H or C1-4alkyl;
- RB is C1-6alkylene-N(H)(C1-6alkyl), C1-6alkylene-(5-8 membered heterocyclyl), C1-6alkylene-C(═O)OH optionally substituted with amine, C1-4alkyl, or benzyl;
- RC is C1-4alkyl or hydroxy;
- and
- n is an integer 0, 1, 2, or 3.
8 more elements
Dependencies are inferred from the claim text.