Process for the synthesis of (s)-edelfosine or (r)-edelfosine
AssigneeRdp Pharma AG
InventorsCheng-Hao Chang, Yu Fa Wang, Roger Marti, Soudani Mylène, Antony Crisp
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Abstract
The present invention relates to an improved method for the synthesis of(S) or (R)-edelfosine ((S) or (R)-CP201).
Claims29
A process for the synthesis of(S)-edelfosine ((S)-CP201) comprising the following steps:
A process for the synthesis of (R)-edelfosine ((R)-CP201) comprising the following steps:
A process for the synthesis of (R)-edelfosine ((R)-CP201) comprising the following steps:
A process for the synthesis of(S)-edelfosine ((S)-CP201) comprising the following steps:
The process according to any one of the preceding claims, wherein compound 6 is prepared according to the following reaction:
Use of ethyl vinyl ether as protecting group in the synthesis of edelfosine (CP201).
A process for the synthesis of compound 11 comprising the following step:
A process for the synthesis of compound 7a′ comprising the following step:
A process for the synthesis of(S)-edelfosine ((S)-CP201) comprising the following steps:
A process for the synthesis of compound 11′ comprising the following step:
A process for the synthesis of compound 7′ comprising the following step:
A process for the synthesis of (R)-edelfosine ((S)-CP201) comprising the following steps:
A compound selected from the following compounds:
A compound selected from the following compounds:
A compound selected from the following compounds:
A compound of the following formula:
Dependencies are inferred from the claim text.