US 2026/0242391 A1Published application

Antimalarial endoperoxide derivatives for the treatment of myelodyplastic syndrome

AssigneeThe Scripps Research Institute

InventorsMichael J. BOLLONG, Priscilla DO, Yuyin LIU, Arnab K. CHATTERJEE

Life of this patent

Estimating the term…

Abstract

Disclosed herein are methods for using an antimalarial endoperoxide compound, such as artemisinin, intreating a subject suffering from myelodysplastic syndromes (MDS), and in slowing or preventing the progression of MDS in the subject to development of acute myeloid leukemia (AML).

Claims27

Dependent claims

A compound of any one of Formulae I-V

wherein
X is X1R1 or Y;
X1 is —O—, —OC(═O)—, —OCH2—, —OCH2C(═O)—, —OCH(CH3)—, —OCH2C(═O)NH—, —CH2—, —N(CH3)—, —NH—, —NHCH2—, —N(CH3)CH2—, —NHCH(CH3)— or —S—;
R1 is —(C1-C6) alkyl, —(C1-C6) heteroalkyl, —(C1-C6) hydroxyalkyl, —(C6-C10) aryl, —(C1-C6) alkyl (C6-C10) aryl, —(C6-C10) aryl-(C1-C6) alkyl, —NH(C6-C10) aryl, —(C5-C10) heteroaryl, —(C1-C6) alkyl (C5-C10) heteroaryl, —(C3-C10) cycloalkyl, —(C1-C6) alkyl (C3-C10) cycloalkyl, —(C2-C6) alkenyl (C3-C10) cycloalkyl, spiro —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C1-C6) alkyl (C3-C10) heterocycloalkyl, —S(═O)2(C1-C6) alkyl, —O—S(═O)2(C1-C6) alkyl, —(C1-C6) alkyl-S(═O)2(C1-C6) alkyl, —(C1-C6) alkyl-S(═O)2NH(C1-C6) alkyl), —(C1-C6) alkyl-S(═O)2N((C1-C6) alkyl)2, —(C1-C6) alkyl-S(═O)2NH2, —(C1-C6) alkyl-NHS(═O)2(C1-C6) alkyl, —(C1-C6) alkyl) C(═O)NH(C1-C6) alkyl, —(C1-C6) alkyl) C(═O)NH2, —C(═O)OH, —(C1-C6) alkyl-C(═O)OH, 2,3-dihydrobenzofuran, 2,3-dihydro-1H-indene, 3,4-dihydroisoquinolin-1(2H)-one, —B(OH)2, —(C1-C6) alkyl-C(═O)O(C1-C6) alkyl, or partially unsaturated fused bicyclic (C3-C10) heterocycloalkyl, wherein any —(C6-C10) aryl, —(C5-C10) heteroaryl, —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C1-C6) alkyl, —O—(C1-C6) alkyl, —(C1-C6) heteroalkyl, or partially unsaturated fused bicyclic (C3-C10) heterocycloalkyl may optionally be substituted with one or more R1′;
each R1′ is independently —OH, halo, oxo, —CN, —NH2, —(C1-C6) alkyl, —(C1-C6) halo alkyl, —O—(C1-C6) halo alkyl, —(C1-C6) alkyl-OH, —CH2C(═O)O(C1-C6) alkyl, —C(═O)O(C1-C6) alkyl, —(C1-C6) alkyl-C(═O)OH, —CH(CH3)C(═O)OH, —C(═O)OH, —C(═O)C(═O)OH, —(C1-C6) heteroalkyl, —O—(C1-C6) alkyl, —S(═O)2(C1-C6) alkyl, —C(═O)NHOH, —C(═O)NH(C1-C6) alkyl, —(C1-C6) alkyl-C(═O)NH(C1-C6) alkyl, —NHS(═O)2(C1-C6) alkyl, —S(═O)2NH2, —S(═O)2NH(C1-C6) alkyl, —S(═O)2N((C1-C6) alkyl)2, —S(═O)2NH—(C3-C10) cycloalkyl, —(C1-C6) alkyl-S(═O)2NH—(C3-C10) cycloalkyl, —S(═O)2CF3, —C(═O)NH2, —(C3-C10) cycloalkyl, —O—(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C5-C10) heteroaryl, —(C1-C6) alkyl (C5-C10) heteroaryl, —C(═O)NH—(C3-C10) cycloalkyl, —NHC(═O)(C3-C10) cycloalkyl, —(C1-C6) alkyl-NHC(═O)(C3-C10) cycloalkyl, —(C1-C6) alkyl-C(═O)(C3-C10) heterocycloalkyl, —C(═O)N(CH3)—(C3-C10) cycloalkyl, —(C1-C6) alkyl-C(═O)NH—(C3-C10) cycloalkyl, —C(═O)NH(C1-C6) alkyl-(C3-C10) cycloalkyl, —(C1-C6) alkyl-C(═O)NH(C1-C6) alkyl-(C3-C8) cycloalkyl, —C(═O)NH—(C3-C10) heterocycloalkyl, —C(═O)NH(C5-C10) heteroaryl, —(C1-C6) alkyl C(═O)NH(C5-C10) heteroaryl, C(═O)NH-thietanyl 1,1-dioxide, —(C1-C6) alkyl-C(═O)OH, —(C2-C6) alkenyl-C(═O)OH, —(C2-C6) alkynyl-C(═O)OH, —CH2C(═O)NH2, —C(═O)NH(C1-C6)alkyl), —C(═O)N((C1-C6)alkyl)2, —(C1-C6) alkyl-C(═O)OH, —(C6-C10) aryl, —C(═O)NH(C6-C10) aryl, —C(═O)NH—(C1-C6) alkyl(C6-C10) aryl, —C(═O)NH—(C1-C6) alkyl-P+(Ph)3, —P+(Ph)3, —B(OH)2, —NHC(═O)—C(═O)OH, or —C(═O)(C3-C10) heterocycloalkyl, wherein any —(C6-C10) aryl, —(C5-C10) heteroaryl, —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C1-C6) alkyl, —O—(C1-C6) alkyl, or —(C1-C6) heteroalkyl may optionally be substituted with one or more R1″;
or two R1′ together form —(C3-C10) cycloalkyl or (C3-C10) heterocycloalkyl, optionally substituted with one or more R1″;
each R1″ is independently —OH, —NH2, —(C1-C6) alkyl, —C(═O)OH, —(C1-C6) alkyl-C(═O)OH, —C(═O)O(C1-C6) alkyl, —CH2C(═O)O(C1-C6) alkyl, —O(C1-C6) alkyl, —(C1-C6) halo alkyl, —O—(C1-C6) halo alkyl, —NHC(═O)OH, —NHC(═O)—(C1-C6) alkyl, —S(═O)2NH2, —S(═O)2NH(C1-C6) alkyl, —S(═O)2N((C1-C6) alkyl)2, —S(═O)2CF3, —C(═O)NH2, —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C5-C10) heteroaryl, oxo, or halo;
and
Y is —(C3-C8) heterocycloalkyl, optionally substituted with one or more R1′;
including enantiomers, racemic and scalemic mixtures, and pharmaceutically acceptable salts thereof.

7 more elements

A compound selected from the group consisting of:

(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methoxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
5-(4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)-2H-tetrazole;
2-(3-methoxy-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
3-(methylsulfonyl)-1-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)azetidine;
N-hydroxy-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamide;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-10-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methoxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzonitrile;
2-(3-methyl-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
4-(3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
(1R,4s)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
2-(4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)picolinic acid;
2-(2,6-difluoro-4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)picolinic acid;
2-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)—N,3,6,9-tetramethyl-N-(2-(methylsulfonyl)ethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzenesulfonamide;
4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzonitrile;
2-(3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
4-(3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
2-(2,6-difluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-(2,3-difluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-fluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
2-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12S,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoic acid;
2-(2-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-(2-fluoro-5-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-(2-((trifluoromethyl)sulfonyl)ethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
2,6-difluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamide;
2,3-difluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)furan-2-carboxylic acid;
2-chloro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
2-(3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)acetic acid;
2-methoxy-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
4-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)ethyl)benzoic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)—N-((2,6-dimethylpyridin-4-yl)methyl)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
5-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)-2H-tetrazole;
2-fluoro-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(1R,4r)-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
2-methyl-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(1S,4s)-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(1S,4r)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
3-methyl-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-fluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
2-((diethylamino)methyl)-5-(1-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)ethyl)phenol;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)—N-((2-fluoropyridin-4-yl)methyl)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzenesulfonamide;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)—N-((2-methoxypyridin-4-yl)methyl)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
2-methyl-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)thietane 1,1-dioxide;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-10-(2-(methylsulfonyl)ethoxy)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
2-methoxy-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid;
(3R,5aS,6R,8aS,9R,10S,12R,12aR)—N-(3-fluorophenyl)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N—((S)-1-(4-(methylsulfonyl)phenyl)ethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-(4-(methylsulfonyl)benzyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
N,N-dimethyl-2-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)ethane-1-sulfonamide;
N-(oxetan-3-yl)-1-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)piperidine-4-carboxamide;
5-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)furan-2-carboxylic acid;
N-(2-((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)ethyl)methanesulfonamide;
1-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)piperidine;
1-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)piperidine-4-carboxylic acid;
N-(1,1-dioxidothietan-3-yl)-1-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)piperidine-4-carboxamide;
1-(2-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)ethyl)piperidine-4-carboxylic acid;
N-methyl-4-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)piperazine-1-carboxamide;
1-(2-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)ethyl)azetidine-3-carboxylic acid;
(R)-1-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)pyrrolidine-3-carboxylic acid;
methyl (R)-1-(2-((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)ethyl)pyrrolidine-3-carboxylate;
(1R,4s)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxylic acid;
5-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)pentanoic acid;
5-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)-2H-tetrazole;
3-methyl-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)bicyclo[2.2.2]octane-1-carboxylic acid;
3-methoxy-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamide;
2-((1S,4s)-4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexyl)acetic acid;
6-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)spiro[3.3]heptane-2-carboxylic acid;
6-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)spiro[3.3]heptane-2-carboxylic acid;
2-((1R,4s)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexyl)acetic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl 4-(dimethylcarbamoyl)benzoate;
(R)-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-(4-fluorophenoxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
2-((1R,3S)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexyl)acetic acid;
2-fluoro-4-(3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
2-fluoro-4-(3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
2-methoxy-4-(3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyl-10-(2-(methylsulfonyl)ethoxy)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
3-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
2-chloro-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl 4-(4-chlorophenyl)-4-hydroxybutanoate;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-phenethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
N-methyl-3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)propenamide;
3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)propenamide;
N-methyl-2-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)ethane-1-sulfonamide;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-(pyridin-4-ylmethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-(2-(methylsulfonyl)ethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-N-(3-(methylsulfonyl)propyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)—N-benzyl-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-amine;
4-((methyl((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)methyl)benzoic acid;
3-(methyl((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)amino)bicyclo[1.1.1]pentane-1-carboxylic acid;
N-(tert-butyl)-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamide;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-10-((4,4-difluorocyclohexyl)methoxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-((4,4-difluorocyclohexyl)methoxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
4′-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-[1,1′-biphenyl]-4-carboxylic acid;
((R)-3-fluoropyrrolidin-1-yl)(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)methanone;
3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)bicyclo[1.1.1]pentane-1-carboxylic acid;
(1R,3s)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclobutane-1-carboxylic acid;
2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-((1,3-dihydroisobenzofuran-5-yl)oxy)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene;
2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
(1S,3r)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclobutane-1-carboxylic acid;
3-methyl-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid;
4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzonitrile;
2-methyl-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)pyridine;
3-chloro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
2-methyl-4-(3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
2-methoxy-4-(3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propan-2-ol;
4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)bicyclo[2.2.1]heptane-1-carboxylic acid;
1-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)cyclopropane-1-carboxylic acid;
1-(4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)cyclopropane-1-carboxylic acid;
2-methyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
1-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclobutane-1-carboxylic acid;
2-oxo-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-oxo-2-(4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-((1R,3S)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclopentyl)acetic acid;
(1R,4s)-4-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propan-2-yl)cyclohexane-1-carboxylic acid;
tert-butyl 2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetate;
3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propiolic acid;
(1R,3S)-3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)cyclopentane-1-carboxylic acid;
(1R,3S)-3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(1R,3S)-3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclopentane-1-carboxylic acid;
3,5-difluoro-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(1S,3R)-3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
3-(4-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propiolic acid;
(1S,4r)-4-fluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)isophthalic acid;
(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)glycine;
(1R,4s)-N-cyclopropyl-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamide;
(2S,5R)-1-methyl-5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)pyrrolidine-2-carboxylic acid;
(3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl 2-(3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate;
3-methyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)butanoic acid;
(1R,3S,5r)-5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1,3-dicarboxylic acid;
1-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)piperidine-4-carboxylic acid;
1-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)azetidine-3-carboxylic acid;
(2S,4R)-4-fluoro-1-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)pyrrolidine-2-carboxylic acid;
(1R,2S,5S)-6,6-dimethyl-3-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;
(1R,3S)-3-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetamido)cyclopentane-1-carboxylic acid;
(1R,4s)-N-(tert-butyl)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamide;
6-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-2,3-dihydrobenzofuran-2-carboxylic acid;
2-(trifluoromethyl)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
((1R,4s)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexyl)methanol;
(1R,5R)-6-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)bicyclo[3.2.0]heptane-3-carboxylic acid;
6-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)bicyclo[3.1.0]hexane-3-carboxylic acid;
(2S,4R)-4-fluoro-1-(2-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)pyrrolidine-2-carboxylic acid;
(2S,4S)-4-hydroxy-1-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)pyrrolidine-2-carboxylic acid;
(R)-1-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)pyrrolidine-3-carboxylic acid;
(1R,2S,5S)-6,6-dimethyl-3-(2-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;
(R)-1-(2-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)pyrrolidine-3-carboxylic acid;
1-(2-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)piperidine-4-carboxylic acid;
3-fluoro-4-(3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)prop-1-yn-1-yl)benzoic acid;
3-fluoro-4-(3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)prop-1-yn-1-yl)benzoic acid;
4-chloro-3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
4-chloro-3-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)boronic acid;
1-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)-2-oxabicyclo[2.1.1]hexane-4-carboxylic acid;
2,2-difluoro-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-phenyl-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propanoic acid;
(1R,3S)-3-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
3-fluoro-4-(3-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propyl)benzoic acid;
3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)cyclobutane-1-carboxylic acid;
(4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)boronic acid;
3,5-dichloro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-chloro-5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-chloro-4-(1-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)ethyl)benzoic acid;
2-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)-2-methylpropanoic acid;
3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)bicyclo[3.1.0]hexane-6-carboxylic acid;
(1R,3s)-3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)cyclobutane-1-carboxylic acid;
2-(3-(trifluoromethyl)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
(S)-3,3-dimethyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)butanoic acid;
(S)-2-cyclobutyl-2-((1R,4R)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)acetic acid;
2-(3-chloro-5-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
(1R,2S)-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)cyclopentane-1-carboxylic acid;
(S)-3,3-dimethyl-2-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetamido)butanoic acid;
(S)-2-phenyl-2-((1R,4R)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)acetic acid;
(1R,2S,5S)-6,6-dimethyl-3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid;
(1S,3aR,6aS)-2-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid;
2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)cyclopropane-1-carboxylic acid;
(1R,4s)-4-methoxy-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(S)-2-amino-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
3-(trifluoromethyl)-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-chloro-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-10-(trifluoromethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-(trifluoromethyl)-4-((((3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
N—((S)-2,6-dioxopiperidin-3-yl)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamide;
(1S,4r)-4-methoxy-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(1R,4s)-4-fluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(1R,3S)-3-((1R,3R)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclobutane-1-carboxamido)cyclopentane-1-carboxylic acid;
(1R,3S)-3-((1R,4R)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)cyclopentane-1-carboxylic acid;
2-oxo-2-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)piperidin-1-yl)acetic acid;
(1S,4s)-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyl-10-(trifluoromethyl)decahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(S)-3-cyclobutyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)propanoic acid;
(1R,3s)-3-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)propan-2-yl)cyclobutane-1-carboxylic acid;
(2S,3aS,6aS)-1-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid;
5-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-1H-indole-2-carboxylic acid;
5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)tetrahydrofuran-2-carboxylic acid;
(3R)-3-fluoro-3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclopentane-1-carboxylic acid;
4-hydroxy-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
(6R)-6-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)tetrahydro-2H-pyran-3-carboxylic acid;
4-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)acetamido)benzoic acid;
6-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-2-naphthoic acid;
3-chloro-5-fluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-chloro-5-(methylsulfonyl)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
3-chloro-5-(methylsulfonyl)-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
2-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)acetic acid;
2-((4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzyl)oxy)acetic acid;
2-(3-fluoro-5-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)acetic acid;
2-methyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)propanoic acid;
3-fluoro-3-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxylic acid;
2-(3-chloro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenoxy)acetic acid;
2-(((1R,4s)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexyl)oxy)acetic acid;
1-(((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-2,3-dihydro-1H-indene-5-carboxylic acid;
1-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-2,3-dihydro-1H-indene-5-carboxylic acid;
3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)cyclopentane-1-carboxylic acid;
(1S,3s)-3-((1R,4S)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)cyclobutane-1-carboxylic acid;
(S)-3,3-dimethyl-2-((1R,4R)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)butanoic acid;
2-(2-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)acetic acid;
(S)-2-cyclohexyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)acetic acid;
(1R,3S)-3-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)cyclopentane-1-carboxylic acid;
(1R,3s)-3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)cyclobutane-1-carboxylic acid;
(S)-2-phenyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)acetic acid;
3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoic acid;
(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)-L-valine;
(S)-4,4,4-trifluoro-2-((1R,4R)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)butanoic acid;
2-(3,5-difluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)acetic acid;
(1R,3S)-3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclopentane-1-carboxylic acid;
(S)-4,4,4-trifluoro-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)butanoic acid;
(1S,3s)-3-((1R,4S)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)cyclobutane-1-carboxylic acid;
(S)-3,3-dimethyl-2-((1R,4R)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)butanoic acid;
(1R,4s)-4-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)cyclohexane-1-carboxylic acid;
1-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)azetidine-3-carboxylic acid;
1-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzyl)-1H-1,2,3-triazole-4-carboxylic acid;
4-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)benzoic acid;
(R)-1-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)pyrrolidine-3-carboxylic acid;
O-methyl-N-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)-L-threonine;
(S)-3-hydroxy-3-methyl-2-((1R,4R)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)butanoic acid;
3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)propanoic acid;
(S)-2-cyclobutyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)acetic acid;
(S)-2-cyclobutyl-2-((1R,4R)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)acetic acid;
(2S,3S,5S,6S,7S,8S)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cubane-1-carboxylic acid;
(S)-3-hydroxy-3-methyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)butanoic acid;
4-((1R,3s)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclobutane-1-carboxamido)cubane-1-carboxylic acid;
(S)-4,4,4-trifluoro-2-((1R,4R)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)butanoic acid;
(S)-2-(4-(trifluoromethyl)phenyl)-2-((1R,3R)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclobutane-1-carboxamido)acetic acid;
(1S,3S,5S)-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzoyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid;
1-((1R,4s)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carbonyl)azetidine-3-carboxylic acid;
(2R,3R,5R,6R,7R,8R)-4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cubane-1-carboxylic acid;
(S)-3-methyl-2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)butanoic acid;
1-((1R,4s)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)cyclohexane-1-carboxamido)cyclopropane-1-carboxylic acid;
(R)-1-((1R,4S)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carbonyl)pyrrolidine-3-carboxylic acid;
1-(2-bromo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzyl)-1H-1,2,3-triazole-4-carboxylic acid;
3-(3-chloro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)oxetane-3-carboxylic acid;
2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)-3-methylbutanoic acid;
(1R,3S)-3-((1R,4R)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)cyclopentane-1-carboxylic acid;
1-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenoxy)cyclopropane-1-carboxylic acid;
(1S,3R)-3-((E)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)prop-1-en-1-yl)cyclohexane-1-carboxylic acid;
2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)-2-methylpropanoic acid;
(1S,4r)-4-fluoro-4-((E)-3-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)prop-1-en-1-yl)cyclohexane-1-carboxylic acid;
(1R,3S)-3-(N-methyl-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)cyclopentane-1-carboxylic acid;
3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)bicyclo[1.1.1]pentane-1-carboxylic acid;
2-(4-((((3S,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenoxy)acetic acid;
(1R,3S)-3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclopentane-1-carboxylic acid;
(2S,4S)-4-fluoro-1-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoyl)pyrrolidine-2-carboxylic acid;
1-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoyl)piperidine-4-carboxylic acid;
(1R,3s)-3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclobutane-1-carboxylic acid;
(R)-2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
3-chloro-5-methyl-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(S)-3,3-dimethyl-2-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)butanoic acid;
(S)-2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)oxetane-3-carboxylic acid;
2-methyl-2-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)propanoic acid;
(2-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)acetyl)-L-valine;
1-((4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)methyl)cyclobutane-1-carboxylic acid;
4-((1R,4s)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)benzoic acid;
(1S,3R,4R)-3-hydroxy-4-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclopentane-1-carboxylic acid;
(1S,3R)-3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclopentane-1-carboxylic acid;
(1R,3R)-3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclohexane-1-carboxylic acid;
6-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)spiro[3.3]heptane-2-carboxylic acid;
(1R,3s)-3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclobutane-1-carboxylic acid;
4-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)bicyclo[2.1.1]hexane-1-carboxylic acid;
(1R,3S)-3-((4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)carbamoyl)cyclopentane-1-carboxylic acid;
4-((1R,4s)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)bicyclo[2.1.1]hexane-1-carboxylic acid;
2-(5,5-dimethyl-2,4-dioxo-3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)imidazolidin-1-yl)acetic acid;
1-(((1R,4s)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)cyclohexane-1-carboxamido)methyl)cyclobutane-1-carboxylic acid;
2-(trifluoromethoxy)-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(1S,3R,4R)-3-hydroxy-4-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclopentane-1-carboxylic acid;
4-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)bicyclo[2.1.1]hexane-1-carboxylic acid;
(S)-2-cyclopropyl-2-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)acetic acid;
(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetyl)-L-valine;
3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)bicyclo[1.1.1]pentane-1-carboxylic acid;
2-(5-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)-1,3,4-oxadiazol-2-yl)acetic acid;
(1S,3R)-3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclopentane-1-carboxylic acid;
(1R,3S)-3-(2-(3-fluoro-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanamido)cyclopentane-1-carboxylic acid;
(1S,3S)-3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclopentane-1-carboxylic acid;
(1R,4s)-4-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclohexane-1-carboxylic acid;
(1R,3S)-3-(3,5-difluoro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclopentane-1-carboxylic acid;
2-(trifluoromethoxy)-5-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoic acid;
(1R,3R)-3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)cyclopentane-1-carboxylic acid;
2-(1-methyl-1H-pyrazol-4-yl)-2-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)acetic acid;
(1S,3R)-3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzamido)cyclopentane-1-carboxylic acid;
(S)-2-acetamido-3-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)propanoic acid;
(1S,2R,3S,4R)-2,3-dihydroxy-4-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclopentane-1-carboxylic acid;
(1R,3S)-3-((4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)benzyl)carbamoyl)cyclopentane-1-carboxylic acid;
(1R,3S)-3-(3-chloro-4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzamido)cyclopentane-1-carboxylic acid;
2-(4-(4-((((3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)-1H-1,2,3-triazol-1-yl)acetic acid;
2-(4-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)-1H-1,2,3-triazol-1-yl)acetic acid;
3-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)propanoic acid;
2-(2-(trifluoromethoxy)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
2-(2-(difluoromethoxy)-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetic acid;
(1R,2S,4R,5S)-4-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)bicyclo[3.1.0]hexane-2-carboxylic acid;
(2S,4R)-4-hydroxy-1-(4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)benzoyl)pyrrolidine-2-carboxylic acid;
(1R,3S)-3-(((4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)methyl)sulfonamido)cyclopentane-1-carboxylic acid;
(1R,3S)-3-((4-((((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)sulfonamido)cyclopentane-1-carboxylic acid;
6-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetamido)spiro[3.3]heptane-2-carboxylic acid;
(1R,3s)-3-((4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)carbamoyl)cyclobutane-1-carboxylic acid;
(S)-1-oxo-7-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;
and
(1R,5S,6S)-3-(2-(4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)phenyl)acetyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid.

328 more elements

Dependencies are inferred from the claim text.

Facts

Application: 19/523,271Filed 5 Aug 2024
Priority: 3 Aug 2023
Published: 20 Aug 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

C07D 493/18
In which the condensed system contains three hetero rings: bridged systems
A61K 31/36
Having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel: compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61K 31/38
Heterocyclic compounds: having sulfur as a ring hetero atom
A61K 31/397
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having four-membered rings, e.g. azetidine

Family

Application63/517,427Us provisional application · filed 3 Aug 2023
US 2026/0242391 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A compound of any one of Formulae I-V

wherein
X is X1R1 or Y;
X1 is —O—, —OC(═O)—, —OCH2—, —OCH2C(═O)—, —OCH(CH3)—, —OCH2C(═O)NH—, —CH2—, —N(CH3)—, —NH—, —NHCH2—, —N(CH3)CH2—, —NHCH(CH3)— or —S—;
R1 is —(C1-C6) alkyl, —(C1-C6) heteroalkyl, —(C1-C6) hydroxyalkyl, —(C6-C10) aryl, —(C1-C6) alkyl (C6-C10) aryl, —(C6-C10) aryl-(C1-C6) alkyl, —NH(C6-C10) aryl, —(C5-C10) heteroaryl, —(C1-C6) alkyl (C5-C10) heteroaryl, —(C3-C10) cycloalkyl, —(C1-C6) alkyl (C3-C10) cycloalkyl, —(C2-C6) alkenyl (C3-C10) cycloalkyl, spiro —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C1-C6) alkyl (C3-C10) heterocycloalkyl, —S(═O)2(C1-C6) alkyl, —O—S(═O)2(C1-C6) alkyl, —(C1-C6) alkyl-S(═O)2(C1-C6) alkyl, —(C1-C6) alkyl-S(═O)2NH(C1-C6) alkyl), —(C1-C6) alkyl-S(═O)2N((C1-C6) alkyl)2, —(C1-C6) alkyl-S(═O)2NH2, —(C1-C6) alkyl-NHS(═O)2(C1-C6) alkyl, —(C1-C6) alkyl) C(═O)NH(C1-C6) alkyl, —(C1-C6) alkyl) C(═O)NH2, —C(═O)OH, —(C1-C6) alkyl-C(═O)OH, 2,3-dihydrobenzofuran, 2,3-dihydro-1H-indene, 3,4-dihydroisoquinolin-1(2H)-one, —B(OH)2, —(C1-C6) alkyl-C(═O)O(C1-C6) alkyl, or partially unsaturated fused bicyclic (C3-C10) heterocycloalkyl, wherein any —(C6-C10) aryl, —(C5-C10) heteroaryl, —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C1-C6) alkyl, —O—(C1-C6) alkyl, —(C1-C6) heteroalkyl, or partially unsaturated fused bicyclic (C3-C10) heterocycloalkyl may optionally be substituted with one or more R1′;
each R1′ is independently —OH, halo, oxo, —CN, —NH2, —(C1-C6) alkyl, —(C1-C6) halo alkyl, —O—(C1-C6) halo alkyl, —(C1-C6) alkyl-OH, —CH2C(═O)O(C1-C6) alkyl, —C(═O)O(C1-C6) alkyl, —(C1-C6) alkyl-C(═O)OH, —CH(CH3)C(═O)OH, —C(═O)OH, —C(═O)C(═O)OH, —(C1-C6) heteroalkyl, —O—(C1-C6) alkyl, —S(═O)2(C1-C6) alkyl, —C(═O)NHOH, —C(═O)NH(C1-C6) alkyl, —(C1-C6) alkyl-C(═O)NH(C1-C6) alkyl, —NHS(═O)2(C1-C6) alkyl, —S(═O)2NH2, —S(═O)2NH(C1-C6) alkyl, —S(═O)2N((C1-C6) alkyl)2, —S(═O)2NH—(C3-C10) cycloalkyl, —(C1-C6) alkyl-S(═O)2NH—(C3-C10) cycloalkyl, —S(═O)2CF3, —C(═O)NH2, —(C3-C10) cycloalkyl, —O—(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C5-C10) heteroaryl, —(C1-C6) alkyl (C5-C10) heteroaryl, —C(═O)NH—(C3-C10) cycloalkyl, —NHC(═O)(C3-C10) cycloalkyl, —(C1-C6) alkyl-NHC(═O)(C3-C10) cycloalkyl, —(C1-C6) alkyl-C(═O)(C3-C10) heterocycloalkyl, —C(═O)N(CH3)—(C3-C10) cycloalkyl, —(C1-C6) alkyl-C(═O)NH—(C3-C10) cycloalkyl, —C(═O)NH(C1-C6) alkyl-(C3-C10) cycloalkyl, —(C1-C6) alkyl-C(═O)NH(C1-C6) alkyl-(C3-C8) cycloalkyl, —C(═O)NH—(C3-C10) heterocycloalkyl, —C(═O)NH(C5-C10) heteroaryl, —(C1-C6) alkyl C(═O)NH(C5-C10) heteroaryl, C(═O)NH-thietanyl 1,1-dioxide, —(C1-C6) alkyl-C(═O)OH, —(C2-C6) alkenyl-C(═O)OH, —(C2-C6) alkynyl-C(═O)OH, —CH2C(═O)NH2, —C(═O)NH(C1-C6)alkyl), —C(═O)N((C1-C6)alkyl)2, —(C1-C6) alkyl-C(═O)OH, —(C6-C10) aryl, —C(═O)NH(C6-C10) aryl, —C(═O)NH—(C1-C6) alkyl(C6-C10) aryl, —C(═O)NH—(C1-C6) alkyl-P+(Ph)3, —P+(Ph)3, —B(OH)2, —NHC(═O)—C(═O)OH, or —C(═O)(C3-C10) heterocycloalkyl, wherein any —(C6-C10) aryl, —(C5-C10) heteroaryl, —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C1-C6) alkyl, —O—(C1-C6) alkyl, or —(C1-C6) heteroalkyl may optionally be substituted with one or more R1″;
or two R1′ together form —(C3-C10) cycloalkyl or (C3-C10) heterocycloalkyl, optionally substituted with one or more R1″;
each R1″ is independently —OH, —NH2, —(C1-C6) alkyl, —C(═O)OH, —(C1-C6) alkyl-C(═O)OH, —C(═O)O(C1-C6) alkyl, —CH2C(═O)O(C1-C6) alkyl, —O(C1-C6) alkyl, —(C1-C6) halo alkyl, —O—(C1-C6) halo alkyl, —NHC(═O)OH, —NHC(═O)—(C1-C6) alkyl, —S(═O)2NH2, —S(═O)2NH(C1-C6) alkyl, —S(═O)2N((C1-C6) alkyl)2, —S(═O)2CF3, —C(═O)NH2, —(C3-C10) cycloalkyl, —(C3-C10) heterocycloalkyl, —(C5-C10) heteroaryl, oxo, or halo;
and
Y is —(C3-C8) heterocycloalkyl, optionally substituted with one or more R1′;
including enantiomers, racemic and scalemic mixtures, and pharmaceutically acceptable salts thereof.

7 more elements

Facts

Application

19/523,271Filed 5 Aug 2024

Priority

3 Aug 2023

Published

20 Aug 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

C07D 493/18
In which the condensed system contains three hetero rings: bridged systems
A61K 31/36
Having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel: compounds containing methylenedioxyphenyl groups, e.g. sesamin
A61K 31/38
Heterocyclic compounds: having sulfur as a ring hetero atom
A61K 31/397
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having four-membered rings, e.g. azetidine