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US 2026/0242340 A1Published application
Compounds and methods for treating protein aggregation diseases
AssigneeAcelot, Inc.
InventorsAmbuj K. SINGH, Jacob B. Schwarz
Life of this patent
Estimating the term…
Abstract
Described herein, inter alia, are compounds and methods for treating protein aggregation diseases.
Claims51
A compound, or a pharmaceutically acceptable salt thereof, having the formula:
- wherein
- n is 0 or 1;
- R1.1 and R1.2 are independently hydrogen, halogen, —C(O)NR1AR1B, or —NR1AC(O)R1C;
- R2.1 and R2.2 are independently hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22, —CN, —SOn2R2D, —SOv2NR2AR2B, —NR2CNR2AR2B, —ONR2AR2B, —NR2CC(O)NR2AR2B, —N(O)m2, —NR2AR2B, —C(O)R2C, —C(O) OR2C, —OC(O)R2C, —OC(O) OR2C, —C(O)NR2AR2B, —OC(O)NR2AR2B, —OR2D, —SR2D, —NR2ASO2R2D, —NR2AC(O)R2C, —NR2AC(O)OR2C, —NR2AOR2C, —SF5, —N3, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
- R1A, R1B, R1C, R2A, R2B, R2C, and R2D are independently hydrogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH, —CONH2, —OCCl3, —OCF3, —OCBr3, —OCI3, —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
- each X2 is independently —F, —Cl, —Br, or —I;
- n2 is an integer from 0 to 4;
- and
- m2 and v2 are independently 1 or 2;
- wherein at least one of R1.1 and R1.2 is not hydrogen;
- and
- wherein the compound is not:
9 more elements
A compound, or a pharmaceutically acceptable salt thereof, having the formula:
- wherein
- n is 0 or 1;
- R1.1 and R1.2 are independently hydrogen, halogen, —CX13, —CHX12, —CH2X1, —OCX13, —OCH2X1, —OCHX12, —CN, —SOn1R1D, —SOv1NR1AR1B, —NR1CNR1AR1B, —ONR1AR1B, —NR1CC(O)NR1AR1B, —N(O)m1, —NR1AR1B, —C(O)R1C, —C(O)OR1C, —OC(O)R1C, —OC(O) OR1C, —C(O)NR1AR1B, —OC(O)NR1AR1B, —OR1D, —SR 1D, —NR1ASO2R1D, —NR1AC(O)R1C, —NR1AC(O) OR1C, —NR1AOR1C, —SF5, —N3, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
- R2.1 and R2.2 are independently hydrogen or halogen;
- R1A, R1B, R1C, and R1D are independently hydrogen, —CCl3, —CBr3, —CF3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH, —CONH2, —OCCl3, —OCF3, —OCBr3, —OCI3, —OCHCl2, —OCHBr2, —OCHI2, —OCHF2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
- each X1 is independently —F, —Cl, —Br, or —I;
- n1 is an integer from 0 to 4;
- and
- m1 and v1 are independently 1 or 2;
- wherein at least one of R2.1 and R2.2 is not hydrogen;
- and
- wherein the compound is not:
9 more elements
Dependencies are inferred from the claim text.