Method for preparing honokiol derivative and intermediate thereof

Abstract

A method for preparing a honokiol derivative and an intermediate thereof is provided. The method includes: subjecting a compound M2 to a Wittig reaction with ethyltriphenylphosphonium bromide under basic conditions to prepare a compound of Formula I, subjecting the compound of Formula I to an allylation reaction to prepare a compound M3, subjecting the compound M3 to MOM deprotection under acidic conditions to prepare a compound M4, and subjecting the compound M4 to a rearrangement reaction to prepare a compound of Formula II. The starting materials of the method are inexpensive and readily available, with low cost, simple steps, mild reaction conditions, low purification requirements, high purity, high yield, environmental friendliness, safety, and suitability for industrial production, having significant application value.

Dependencies are inferred from the claim text.