Methods for producing transplantable cartilage tissue
AssigneeCo.Don AG
InventorsGiulietta Roel, Christian Kaps, Claudia Eschen
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Abstract
The present invention relates to a method for producing cartilage tissue by selecting and choosing from chondrocytes or spheroids, and use thereof as pharmaceutical composition, medicinal product or transplant. In particular, the invention relates to markers for identifying suitable chondrocytes for producing cartilage tissue, in particular for the purpose of transplantation.
Claims14
Isolated spheroids comprising chondrocytes embedded in an extracellular matrix that contains type II collagen and aggrecan, wherein the plurality of spheroids express cartilage acidic protein 1 (CRTAC1) and at least one of neuritin 1 (NRN1) and aggrecan (ACAN), and express early B-cell factor 3 (EBF3) below a predetermined threshold value.
Dependencies are inferred from the claim text.