Method for Preparing a Sterile Hydrogel Comprising a Cross-Linked or Non-Crosslinked Polysaccharide or a Mixture Thereof
AssigneeTeoxane
InventorsRomain BRUSINI, Camille VANTOU, Jimmy FAIVRE, François BOURDON
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Abstract
The disclosure relates to a method for preparing a sterile hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide, or a mixture thereof, the method comprising the following steps: (1) preparing a hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or mixture thereof and further comprising at least 1 mM citrate ions; and (2) sterilizing, preferably by heat, the hydrogel comprising at least 1 mM citrate ions to obtain a sterile hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof.
Claims19
A method for preparing a sterile hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide, or a mixture thereof, the method comprising the following steps:
- (1) preparing a hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or mixture thereof and further comprising at least 1 mM citrate ions;
- and
- (2) sterilizing the hydrogel comprising at least 1 mM citrate ions to obtain a sterile hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof.
The method according to claim 17, wherein the physiologically acceptable buffer is a phosphate buffer.
A method for protecting a hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof from degradation of its rheological properties during sterilization comprising the addition of citrate ions in the hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof.
A method for preserving the stability over time of a hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof comprising the addition of citrate ions in the hydrogel comprising a cross-linked polysaccharide, a non-cross-linked polysaccharide or a mixture thereof.
Dependencies are inferred from the claim text.