Porous 3d matrix based on polyelectrolyte complexes and uses thereof

Abstract

The present invention relates to a porous matrix of polyelectrolyte complexes (PEC) based on alginate and chitosan or derivatives thereof, which is particularly suitable for cell therapy and in particular for the healing of soft tissues and tissue repair. The matrix according to the invention can advantageously be used in combination with macrophages in order to promote wound healing. The invention also relates to a hybrid biomaterial comprising such a porous matrix and pro-wound-healing macrophages, and optionally mesenchymal stromal cells, and to a kit comprising this matrix. The present invention also relates to a method for preparing such a matrix, to a method for preparing such a hybrid biomaterial, and to the use of such a hybrid biomaterial in regenerative medicine.

Dependencies are inferred from the claim text.