Functional nucleic acid molecule and method
AssigneeThe University Court of the University of Edinburgh
InventorsSteven Pollard, Mantas Matjusaitis
Life of this patent
Estimating the term…
Abstract
Disclosed are constructs configured to express adverse (for example cytotoxic and immunomodulatory) payloads in cells, which constructs may be used to treat or prevent recurrent/secondary cancer/tumours and to prime, induce, raise or promote an immune response which is effective against a recurrent/secondary cancer/tumour which might arise from said primary cancer/tumour.
Claims22
A method of (i) treating or preventing a recurrent/secondary cancer/tumour and/or (ii) raising, priming or inducing an anti-recurrent/secondary cancer/tumour immune response, comprising:
- administering a construct or functional nucleic acid to a patient, said construct or functional nucleic acid comprising a gene or transgene encoding an adverse payload.
A method of (i) treating or preventing a recurrent/secondary cancer/tumour and/or (ii) raising, priming or inducing an anti-recurrent/secondary cancer/tumour immune response, comprising:
- administering a construct or functional nucleic acid to a patient, said construct or functional nucleic acid comprising a gene or transgenes encoding IL-12 and herpes simplex virus thymidine kinase (HSV-TK).
Dependencies are inferred from the claim text.