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US 2026/0241004 A1Published application
Injectable suspension or emulsion of coated magnetite nanoparticles for use in the treatment of solid tumors
AssigneeA Vision Inc.
InventorsAndrea AGAZZI, Angelo COLOMBO
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Abstract
The invention relates to an injectable suspension or emulsion of magnetite nanoparticles coated with an organic layer, that can be used in the treatment of solid tumors.
Claims20
An injectable composition for percutaneous administration in a solid tumor via direct injection in the tumor mass, consisting in a suspension or emulsion of magnetite nanoparticles coated with an organic layer, selected between:
- A) a suspension in water added with a surfactant and one or more between a buffer system and a stabilizer;
- and
- B) a water-based lipidic suspension or emulsion, added with one or more components selected among egg phosphatide, medium chain triglycerides, long chain triglycerides, glycerol, linoleic acid, cholesterol, and sodium oleate,
- said injectable composition having the following features:
- it is sterile and pyrogen-free;
- it is isotonic with bodily fluids;
- the pH of the injectable compositions is between 7.8 and 8.2;
- the concentration of magnetite nanoparticles in the injectable compositions in the range 10-30 mM.
5 more elements
Dependencies are inferred from the claim text.