T-cells comprising chimeric antigen receptors and compositions thereof for treatment of cancer

Abstract

T-cells comprising chimeric antigen receptors (CARs) for the treatment of cancer. The CARs include a Protein Tyrosine Phosphatase Receptor Type D (PTPRD) domain or a single chain variable fragment of an antibody that binds to IL-1RAP expressed by cancer cells, a transmembrane domain, and domains or fragments of co-stimulatory molecules. The CAR T-cells have high specificity for IL1-1RAP expressed on the surface of cancer cells. Nucleic acids and vectors encoding the CAR T-cells and a method for production of the CAR T-cells are additional aspects.

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