Fusion polypeptides, immunogenic compositions, methods and uses thereof
AssigneeUniversity of Saskatchewan
InventorsArinjay Banerjee, Darryl Falzarano, Qiang Liu, Alyson Ann Kelvin
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Abstract
Fusion polypeptides, and their use in subunit vaccine compositions to elicit immune responses against two or more pathogens are described, as well as polynucleotides encoding therefor. Also described are methods for treating and preventing infection by two or more pathogens.
Claims49
A fusion polypeptide comprising an amino acid sequence encoding, in sequence, a first antigen, a linker, and at least one additional antigen.
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A fusion polypeptide comprising an amino acid sequence encoding a plurality of antigens in series, wherein each of the plurality of antigens is linked with a linker sequence to the preceding antigen.
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A fusion polypeptide of any one of SEQ ID NOs:
- 1 to 11 or a sequence with at least 90% identity, at least 91% identity, at least 92% identity, at least 93% identity, at least 94% identity, at least 95% identity, at least 96% identity, at least 97% identity, at least 98% identity, at least 99% identity to any one of SEQ ID NOs:
- 1 to 11, respectively.
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Dependencies are inferred from the claim text.