Engineered nipah virus mrna vaccine

Abstract

Provided herein are a Nipah virus vaccine composition including (i) a messenger ribonucleic acid (mRNA) including an open reading frame (ORF) encoding soluble Nipah virus glycoprotein (soluble NiV-G) fused with human collagen type I alpha 1 (COL1A1) signal peptide, (ii) a mRNA including an ORF encoding full-length Nipah virus glycoprotein (full-length NiV-G), (iii) a mRNA including an ORF encoding full-length Nipah virus fusion protein (full-length NiV-F), or (iv) the mRNA including the ORF encoding full-length NiV-G, and the mRNA including the ORF encoding full-length NiV-F, and a method of inducing immune response against Nipah virus by administering an effective amount of the Nipah virus vaccine composition to a subject in need thereof.

Dependencies are inferred from the claim text.