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AssigneeAgency for Science, Technology and Research
InventorsLai Guan Ng, Shu Zhen Chong, Ye Chean Teh, Ming Yao Chooi, Swaine Chen
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The present invention relates to uses of O-antigens for treating bacterial infections. In one aspect of the present invention, there is provided a use of an O-antigen in the manufacture of a medicament for treating a bacterial infection, wherein the medicament to be administered mobilises transitional premonocytes (TpMos) from a bone marrow into a peripheral blood of a subject. In another aspect, there is provided an O-antigen for use in treating a bacterial infection, wherein the O-antigen mobilises TpMos from a bone marrow into a peripheral blood of a subject. In another aspect, there is provided a method of mobilizing proliferating transitional premonocytes (TpMos) from a bone marrow into a peripheral blood of a subject, the method comprising administering to the subject a therapeutically effective amount of an O-antigen.
Use of an O-antigen in the manufacture of a medicament for treating a bacterial infection, wherein the medicament to be administered mobilises transitional premonocytes (TpMos) from a bone marrow into a peripheral blood of a subject.
A pharmaceutical composition comprising (a) a therapeutically effective amount of an O-antigen comprising the structure DGIc-(a1-4)-DGal(a1-3)-DGIcNAc;
An O-antigen for use in treating a bacterial infection, wherein the O-antigen mobilises TpMos from a bone marrow into a peripheral blood of a subject.
A method for treating a bacterial infection comprising administering to a subject a therapeutically effective amount of a composition comprising an O-antigen, wherein the administration of the O-antigen mobilises transitional premonocytes (TpMos) from a bone marrow into a peripheral blood of the subject.
A method of mobilizing transitional premonocytes (TpMos) from a bone marrow into a peripheral blood of a subject, the method comprising administering to the subject a therapeutically effective amount of an O-antigen.
A method of determining a prognosis of a subject having sepsis induced by a Gram-negative bacterial infection, the method comprising detecting a presence of transitional premonocytes (TpMos) in a blood sample obtained from the subject, wherein the presence of TpMos in the blood sample is indicative of a favourable clinical outcome.
Dependencies are inferred from the claim text.