Compositions and Methods for Treating Fentanyl Dependence
AssigneeBabak Behnam
InventorsBabak Behnam, Azim Akbarzadehkhiavi
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Abstract
This invention provides a composition of matter comprising a plurality of fentanyl-glutaryl-BSA, wherein the average ratio of fentanyl-glutaryl moieties to BSA is at least 7.0. This invention also provides related pharmaceutical compositions, therapeutic methods, prophylactic methods, synthetic methods, and articles of manufacture.
Claims17
-34. (canceled)
A composition of matter comprising a plurality of fentanyl-glutaryl-bovine serum albumin (BSA), wherein the average ratio of fentanyl-glutaryl moieties to BSA is selected from the group consisting of at least 7.0, at least 7.5, at least 8.0, and at least 8.2.
A method for making fentanyl-glutaryl-BSA, comprising the following steps (a) and (b):
- (a) contacting fentanyl with glutaric acid in the presence of benzene under conditions permitting the formation of fentanyl-glutarate;
- and
- (b) contacting the resulting fentanyl-glutarate with BSA under conditions permitting the formation of fentanyl-glutaryl-BSA, wherein (i) such conditions comprise the presence of tributylamine, dioxane, and isobutyl chloroformate, and (ii) neither step (a) nor step (b) is performed in the presence of EDAC, or
- alternatively comprising the following step (c):
- (c) contacting fentanyl-glutarate with BSA under conditions permitting the formation of fentanyl-glutaryl-BSA, wherein (i) such conditions comprise the presence of tributylamine, dioxane, and isobutyl chloroformate, and (ii) the contacting is performed in the absence of EDAC.
Dependencies are inferred from the claim text.