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US 2026/0240949 A1Published application
Methods for treating neurodegenerative disorders
AssigneesPresident and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
InventorsLee L. Rubin, Amy J. Wagers, Richard T. Lee, Lida Katsimpardi
Life of this patent
Estimating the term…
Abstract
Methods and compositions for rejuvenating neural stem cells and/or progenitor cells, increasing neurogenesis, increasing angiogenesis, and treating or preventing neurodegenerative and neurovascular disorders are disclosed.
Claims20
A method of increasing SMAD phosphorylation in a subject, comprising:
- administering to the subject an amount of an agent or composition effective to increase the level of GDF11 polypeptide in one or more of a systemic circulation, cerebral vasculature, neurovasculature, cerebral tissue, cerebrospinal fluid, lateral ventricles, and subventricular zone of the subject.
A method of treating or preventing a neurodegenerative disorder in a subject in need thereof, comprising:
- administering to the subject an amount of a composition comprising a GDF11 polypeptide or a functional fragment or variant thereof capable of activating or modulating an ALK4/5 receptor, thereby treating or preventing the neurodegenerative disorder in the subject.
A method of treating or preventing multiple sclerosis in a subject in need thereof, comprising:
- administering to the subject a composition comprising a GDF11 polypeptide or a functional fragment or variant thereof capable of activating or modulating an ALK4/5 receptor, thereby treating or preventing multiple sclerosis in the subject.
Dependencies are inferred from the claim text.