Treatment and prevention of agent-induced liver conditions or diseases
AssigneeFarsight Medical Technology (Shanghai) Co., Ltd.
InventorsJia XIAO, Ching Pong Mak, Fashu Ma, Dong Xiao, Kwok Fai So, Zhaodi Che
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Abstract
Provided herein is Compound 1 or a pharmaceutically acceptable salt thereof for use in the prevention and/or treatment of a liver condition or disease in a subject exposed to an agent capable of inducing the liver condition or disease.
Claims35
Use of Compound 1 or a pharmaceutically acceptable salt thereof
- in the manufacture of a medicament for the prevention and/or treatment of a liver condition or disease in a subject exposed to an agent capable of inducing the liver condition or disease.
The use according to any one of the preceding claims, wherein the subject has a pre-existing condition or disease that increases the subject's risk of developing a liver condition or disease when exposed to the agent.
The use according to any one of the preceding claims, wherein the agent induces oxidative stress in the liver.
The use according to any one of the preceding claims, wherein the agent induces necrosis of the liver.
The use according to any one of the preceding claims, wherein the agent induces inflammation of the liver.
The use according to any one of the preceding claims, wherein the agent induces an elevation of ALT and AST biomarkers.
The use according to any one of the preceding claims, wherein Compound 1 is administered at a dosage of about 0.001 to about 10 mg/kg, about 0.1 to about 10 mg/kg, or about 5 mg/kg to about 10 mg/kg.
The use according to any one of the preceding claims, wherein the subject is a human subject.
The use according to any one of the preceding claims, wherein the medicament is formulated for administration by injection or infusion, preferably subcutaneous, intramuscular, or intravenous injection, or intravenous or subcutaneous infusion.
The use according to any of the preceding claims, wherein the medicament is formulated for administration by injection or infusion, preferably intravenous injection or infusion.
Dependencies are inferred from the claim text.