Heat-treated extended-release formulations
AssigneeVitaKey Inc.
InventorsAaron C. Anselmo, Anant Shankar Balijepalli, Andrew D. Christenson, Joshua K. DeGennaro, Andrea Stamp, Ana Jaklenec, Catherine B. Reynolds, Robert S. Langer, Christina Lynn Makris, Sarah Grace Adzema, Thomas Pho, Megan Elizabeth Reynolds
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Abstract
The present disclosure provides heat-treated extended-release formulations comprising one or more food components and one or more release modulators. The present example also provides methods of manufacturing heat-treated extended-release formulations.
Claims46
1-82. (canceled)
A preparation of particles comprising:
- 60% (w/w) to 85% (w/w) heat-treated protein;
- 5% (w/w) to 20% (w/w) pectin or carrageenan;
- 0.5% (w/w) to 1.5% (w/w) alginate;
- and
- 0.5% (w/w) to 8% (w/w) gelator,
- which particle preparation is an extended-release particle preparation in that, when the particles are incubated in a solution of simulated gastric fluid comprising 60 units/ml of pepsin at 37° C., the protein is released over a period of time that extends for at least 2 hours, and further wherein:
- at least 5% of the protein is released over a duration of 2 hours;
- and
- at least 50% of the protein is released over a duration of 6 hours.
101-103. (canceled)
A food, beverage, or supplement product comprising a particle preparation that releases protein in simulated gastric fluid over a period of time that extends for at least two hours so that the particle preparation is an extended-release particle preparation, wherein particles of the preparation comprise:
- 60% (w/w) to 85% (w/w) heat-treated protein;
- 5% (w/w) to 20% (w/w) pectin or carrageenan;
- 0.5% (w/w) to 1.5% (w/w) alginate;
- and
- 0.5% (w/w) to 8% (w/w) gelator,
- and further wherein the extended-release particle preparation is characterized in that, when the particles are incubated in a solution of simulated gastric fluid comprising 60 units/ml of pepsin at 37° C., the protein is released over a period of time that extends for at least 2 hours, and further wherein:
- at least 5% of the protein is released over 2 hours;
- and
- at least 50% of the protein is released over 6 hours.
109-111. (canceled)
Dependencies are inferred from the claim text.