Repair and/or reconstruction of invertebral discs
AssigneeMesoblast, Inc.
InventorPeter Ghosh
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Abstract
This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1+ multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.
Claims8
1-8. (canceled)
A method for treating low back pain caused by a degenerated intervertebral disc in a human subject, the method comprising administering into the annulus fibrosus (AF) of the degenerated intervertebral disc a therapeutically effective amount of a composition comprising a culture-expanded population of allogeneic human cells enriched for non-hematopoietic, STRO-1+, TNAP+ multipotential cells and/or progeny cells thereof, wherein the administration of the composition restores the degenerated intervertebral disc by secreting paracrine factors into the disc space.
Dependencies are inferred from the claim text.