Tcr molecules targeting kras mutation, cells and use of tcr molecules and cells

A binding protein, which comprises a binding domain having antigen specificity for an antigen peptide:HLA complex, wherein the binding domain comprises a T cell receptor (TCR) α chain variable region and a TCR β chain variable region, wherein:

• 1) the antigen peptide comprises the amino acid sequence of VVVGADGVGK (SEQ ID NO:
• 1);
• the HLA is HLA-A*11:01;
• CDR3 of the α chain variable region comprises the amino acid sequence of SEQ ID NO:
• 7, 17, 27, 37, 47, or 57, or an amino acid sequence having at least 80% identity or 90% identity to the amino acid sequence of SEQ ID NO:
• 7, 17, 27, 37, 47, or 57;
• CDR3 of the β chain variable region comprises the amino acid sequence of SEQ ID NO:
• 12, 22, 32, 42, 52, or 62, or an amino acid sequence having at least 80% identity or 90% identity to the amino acid sequence of SEQ ID NO:
• 12, 22, 32, 42, 52, or 62;
• or
• 2) the antigen peptide comprises the amino acid sequence of KLVVVGAVGV (SEQ ID NO:
• 2);
• the HLA is HLA-A*02:01;
• CDR3 of the α chain variable region comprises the amino acid sequence of SEQ ID NO:
• 67, 77, 87, 97, 107, 117, 127, 137, 147 or 157, or an amino acid sequence having at least 80% identity or 90% identity to the amino acid sequence of SEQ ID NO:
• 67, 77, 87, 97, 107, 117, 127, 137, 147 or 157;
• CDR3 of the β chain variable region comprises the amino acid sequence of SEQ ID NO:
• 72, 82, 92, 102, 112, 122, 132, 142, 152 or 162, or an amino acid sequence having at least 80% identity or 90% identity to the amino acid sequence of SEQ ID NO:
• 72, 82, 92, 102, 112, 122, 132, 142, 152 or 162.