Short interspersed nuclear repeat element rna of imprinted micro-rna clusters mediate intrinsic type iii interferon-driven viral resistance
AssigneeUniversity of South Florida
InventorHana TOTARY-JAIN
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Abstract
The present disclosure describes methods of inducing type III IFN stimulated genes in fetal trophoblast cells to decrease or inhibit vertical transmission of viral infection to the fetus. The method comprises induction of short interspersed nuclear elements in a microRNA cluster.
Claims23
A method for reducing the likelihood of amniotic fluid infection and/or fetal infection, or treating amniotic fluid infection and/or fetal infection, the method comprising:
- vaginally administering to a pregnant female a composition comprising an in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), or fragments thereof, wherein the SINEs or fragments thereof comprise Alu repeats.
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A method for preparing a cell, tissue, or an organ for transplant in a recipient, the method comprising:
- contacting the cell, tissue, or organ with a composition comprising an in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), or fragments thereof, wherein the SINEs or fragments thereof comprise Alu repeats.
A method of treating wounded tissue in a subject in need thereof, the method comprising:
- administering to the wounded tissue a composition comprising an in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), or fragments thereof, wherein the SINEs or fragments thereof comprise Alu repeats.
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Dependencies are inferred from the claim text.