Methods of reducing transplant rejection in subjects undergoing immunosuppressant therapy
AssigneeUniversity of Maryland, Baltimore
InventorsBing Ma, Jonathan S. Bromberg
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Abstract
The present invention provides a method of reducing transplant rejection in a subject undergoing an immunosuppressant therapy, comprising detecting a dysbiotic state in the subject's gut microbiota resulting from the immunosuppressant therapy; and administering a therapy that attenuates the dysbiotic state in the subject's gut microbiota.
Claims70
A method of reducing transplant rejection in a subject undergoing an immunosuppressant therapy, comprising
- i) detecting a dysbiotic state in the subject's gut microbiota resulting from the immunosuppressant therapy;
- and
- ii) administering to the subject a therapy that attenuates the dysbiotic state in the subject's gut microbiota.
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A method of reducing transplant rejection in a subject undergoing an immunosuppressant therapy, comprising
- i) detecting a dysbiotic state in the subject's gut microbiota resulting from the immunosuppressant therapy;
- and
- ii) stopping the immunosuppressant therapy in the subject and administering to the subject a different immunosuppressant therapy.
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A method of reducing transplant rejection in a subject undergoing an immunosuppressant therapy, comprising administering to the subject an effective amount of pro-tolerogenic microbes that attenuate a dysbiotic state in the subject's gut microbiota or an effective amount of a metabolomic composition that attenuates a dysbiotic state in the subject's gut microbiota.
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Dependencies are inferred from the claim text.